Zongliang (Carl) Jiang

Title Assistant Professor
Department School of Animal Sciences
E-mail ZJiang@agcenter.lsu.edu
Address 1 229B AFSL Building
Baton Rouge, LA 70803
Phone 225-578-5037
Fax 225-578-4890

  • Ph.D., Reproductive Physiology, University of Connecticut, 2015
  • Postdoctoral Associate, Reproductive Biology, University of Connecticut, 2015 - 2016
  • Postdoctoral Associate, Reproductive Biology, School of Medicine, Yale University, 2016 - 2017

  • 2017 - Present, Assistant Professor, School of Animal Sciences, AgCenter, Louisiana State University

  • Placental trophoblast differentiation and function, and diseases of pregnancy.
  • Epigenetic mechanisms of early embryo development.
  • Environmental stress effects on reproduction and epigenetics and its long-range consequences.
  • Pluripotent stem cells in regenerative medicine applications.

  • A novel goat model to characterize the male fertility following paternal cannabis exposure. Therapeutic Cannabis Research (LA TCRC), Principal Investigator. 07/01/2021 - 06/30/2022
  • Epigenetic mechanisms in placental trophoblast development. NIH/NICHD R01, Principal Investigator. 08/01/2020 - 04/30/2025
  • Reconstitution of the oogonia from pluripotent stem cells in vitro - a comparative equine and bovine model to study in vitro oogenesis. ACRES, Principal Investigator. 07/01/2020 - 06/30/2021
  • Fibro/adipogenic Progenitors and Beef Quality. USDA-NIFA, Co-Principal Investigator. 04/01/2020 - 03/31/2024
  • Epigenetic regulation of bovine preimplantation embryo development. USDA-NIFA, Principal Investigator. 07/01/2019 - 06/30/2023
  • Molecular determinants of bovine oocytes and embryos viability. LA Board of Regents, Principal Investigator. 06/01/2019 - 05/30/2023
  • Single cell genomics reconstruction of development trajectories in embryos. The Colorado Foundation for Embryo Research, Principal Investigator. 2019 - present
  • Reconstitution of the bovine oogonia from pluripotent stem cells in vitro. ACRES, Principal Investigator. 07/01/2019 - 06/30/2020
  • CRISPR-based chromatin remodeling of the endogenous pluripotent genes enables generation of bovine induced pluripotent stem cells for use in nuclear transfer. ACRES, Principal Investigator. 07/01/2018 - 06/30/2019

Peer-reviewed publications (*Co-first author, #Corresponding author)

  • Zhu L, Marjani SL, Jiang Z#. The epigenetics of gametes and early embryos and potential long-range consequences in livestock species - filling in the picture with epigenomic analyses. Frontiers in Genetics. 2021 Mar 2; 12:557934. PMID: 33747031.
  • Iyyappan R, Aleshkina D, Zhu L, Jiang Z, Kinterova V, Susor A. Oocyte specific LncRNA variant Rose influences oocyte and embryo development. Non-coding RNA research. Volume 6, Issue 2, June 2021, Pages 107-113.
  • Gutierrez E, Ming H, Foster B, Gatenby L, Mak CK, Pinto C, Bondioli K, Jiang Z#. Effect of vitrification on global gene expression dynamics of bovine elongating embryos. Reprod Fertil Dev. 2021 February 19. PMID: 33602389.
  • Li Z, Zhao S, Nelakanti RV, Lin K, Wu TP, Alderman III MH, Guo C, Wang P, Zhang M, Wang M, Jiang Z, Wang Y, Li H, Xiao AZ. N6-methyladenine in DNA antagonizes SATB1 in early development. Nature. 2020 Jul 15: 583, 625–630. PMID: 32669713.
  • Ming H, Sun J, Pasquariello R, Gatenby L, Herrick J, Yuan Y, Pinto C, Bondioli KR, Krisher RL, Jiang Z#. The landscape of accessible chromatin in bovine oocytes and early embryos. Epigenetics. 2020 July 14. PMID: 32663104.
  • Smith R*, Jiang Z*, Susor A, Ming Hao, Tait J, Conti M, Lin CJ. The H3.3 chaperone Hira complex orchestrates oocyte developmental competence. bioRxiv. 2020 May 26.
  • Li Y, Sun J, Ling Y, Hao M, Chen Z, Fang F, Liu Y, Cao H, Ding J, Cao Z, Zhang X, Bondioli K, Jiang Z#, Zhang Y. Transcriptional profiles of oocytes during maturation and embryos during preimplantation development in vivo in the goat. Reprod Fertil Dev. 2020 Apr;32(7):714-725. PMID: 32317096.
  • Esencan E*, Jiang Z*, Wang T, Zhang M, Soylemez-Imamoglu G, Seli E#. Impaired mitochondrial stress response due to CLPP deletion is associated with altered mitochondrial dynamics and increased apoptosis in cumulus cells. Reproduction Sciences. 2020 Jan 14. PMID: 31939198.
  • West R*, Ming H*, Logsdon D*, Sun J, Rajput S, Kile R, Schoolcraft W, Roberts M, Krisher R, Jiang Z#, Yuan Y#. Dynamics of trophoblast differentiation in peri-implantation stage human embryos. PNAS. 2019 Oct 21. PMID: 31636193.
  • Zhang M, Bener MB, Jiang Z, Wang T, Esencan E, Scott R, Horvath T, Seli E. Mitofusin 1 is required for female fertility and to maintain ovarian follicular reserve. Cell Death & Disease, 2019 Jul 22;10(8):560. PMID: 31332167.3.
  • Zhang M, Bener MB, Jiang Z, Wang T, Esencan E, Scott R, Horvath T, Seli E. Mitofusion 2 plays a role in oocyte and follicle development, and is required to maintain ovarian follicular reserve during reproductive aging. Aging, 2019 Jun 16;11(12):3919-3938. PMID: 31204316.4.
  • Duan J*, Jiang Z*, Alqahtani F, Mandoiu I, Hong D, Zheng X, Marjani SL, Chen J, Tian XC. Methylome dynamics of bovine gametes and in vivo early embryos. Front Genet. 2019 May 28; 10:512. PMID: 31191619.5.
  • Duan J, Zhu L, Dong H, Zheng X, Jiang Z, Chen J, Tian XC. Abundance of mRNA for histone variants, histone- and DNA-modifying enzymes in bovine in vivo and in vitro oocytes and embryos. Sci Rep. 2019 Feb 4;9(1):1217. PMID: 30718778.6.
  • Duan JE, Flock K, Jue N, Zhang M, Jones A, Seesi S, Mandoiu I, Pillai S, Hoffman M, O’Neill R, Zinn S, Govoni K, Reed S, Jiang H, Jiang Z, Tian XC. Dosage compensation and gene expression of the X chromosome in sheep. G3:GenesGenomesGenetics. 2019. Jan 9;9(1):305-314. PMID: 30482800.7.
  • Duan J, Shi W, Jue N, Jiang Z, Kuo L, O’Neill R, Wolf E, Dong H, Zheng X, Chen J; Tian XC. Dosage Compensation of the X Chromosomes in Bovine Germline, Early Embryos and Somatic Tissues. Genome Biology and Evolution, 2019 Jan 1;11(1):242-252. PMID: 30566637.20188.
  • Duan JE, Zhang M, Flock K, Seesi SA, Mandoiu I, Jones A, Johnson E, Pillai S, Hoffman M, McFadden K, Jiang H, Reed S, Govoni K, Zinn S, Jiang Z, Tian XC. Effects of maternal nutrition on the expression of genomic imprinted genes in ovine fetuses. Epigenetics. 2018; 13(8):793-807. PMID: 30051747.9.
  • Jiang Z, Lin J, Dong H, Zheng X, Marjani SL, Duan J, Ouyang Z, Chen J, Tian XC. DNA methylomes of bovine gametes and in vivo produced preimplantation embryos. Biology of Reproduction. 2018 Jun 14. PMID: 29912291.
  • Wang T, Babayev E, Jiang Z, Li G, Zhang M, Esencan E, Horvath T, Seli E. Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre-implantation embryos. Aging Cell. 2018 May 30:e12784. doi:10.1111/acel.12784. [Epub ahead of print] PubMed PMID: 29851234.
  • Wang L*, Jiang Z*, Huang D, Duan J, Huang C, Sullivan S, Vali K, Yin Y, Zhang M, Wegrzyn J, Tian XC, Tang Y. JAK/STAT3 regulated global gene expression dynamics during late-stage reprogramming process. BMC Genomics. 2018 Mar 6;19(1):183. doi:10.1186/s12864-018-4507-2. PubMed PMID: 29510661; PubMed Central PMCID: PMC5840728.
  • Wang L, Huang D, Jiang Z, Luo Y, Norris C, Zhang M, Tian X, Tang Y. Akt3 is responsible for the survival and proliferation of embryonic stem cells. Biol Open. 2017 Jun 15;6(6):850-861. doi: 10.1242/bio.024505. PubMed PMID: 28483982; PubMed Central PMCID: PMC5483023.
  • Wang T, Zhang M, Jiang Z, Seli E. Mitochondrial dysfunction and ovarian aging. Am J Reprod Immunol. 2017 May;77(5). doi: 10.1111/aji.12651. Epub 2017 Feb 13. Review. PubMed PMID: 28194828.
  • Tribulo P, Moss JI, Ozawa M, Jiang Z, Tian XC, Hansen PJ. WNT regulation of embryonic development likely involves pathways independent of nuclear CTNNB1. Reproduction. 2017 Apr;153(4):405-419. doi: 10.1530/REP-16-0610. Epub 2017 Jan 9. PubMed PMID: 28069902.
  • Sun J*, Jiang Z*, Tian X, Bi J. A cross-species bi-clustering approach to identifying conserved co-regulated genes. Bioinformatics. 2016 Jun 15;32(12):i137-i146. doi: 10.1093/bioinformatics/btw278. PubMed PMID: 27307610;PubMed Central PMCID: PMC4908362.
  • Jiang Z, Harrington P, Zhang M, Marjani SL, Park J, Kuo L, Pribenszky C, Tian XC. Effects of High Hydrostatic Pressure on Expression Profiles of In Vitro Produced Vitrified Bovine Blastocysts. Sci Rep. 2016 Feb 17;6:21215. doi: 10.1038/srep21215. PubMed PMID: 26883277; PubMed Central PMCID: PMC4756375.
  • Jiang Z, Dong H, Zheng X, Marjani SL, Donovan DM, Chen J, Tian XC. mRNA Levels of Imprinted Genes in Bovine In Vivo Oocytes, Embryos and Cross Species Comparisons with Humans, Mice and Pigs. Sci Rep. 2015 Dec 7;5:17898. doi: 10.1038/srep17898. PubMed PMID: 26638780; PubMed Central PMCID: PMC4671149.
  • Jiang Z, Tang Y, Zhao X, Zhang M, Donovan DM, Tian XC. Knockdown of Brm and Baf170, Components of Chromatin Remodeling Complex, Facilitates Reprogramming of Somatic Cells. Stem Cells Dev. 2015 Oct 1;24(19):2328-36. doi: 10.1089/scd.2015.0069. Epub 2015 Jun 29. PubMed PMID: 26121422; PubMed Central PMCID: PMC4582692.
  • Jiang Z, Sun J, Dong H, Luo O, Zheng X, Obergfell C, Tang Y, Bi J, O'Neill R, Ruan Y, Chen J, Tian XC. Transcriptional profiles of bovine in vivo pre-implantation development. BMC Genomics. 2014 Sep 4;15:756. doi:10.1186/1471-2164-15-756. PubMed PMID: 25185836; PubMed Central PMCID: PMC4162962.
  • Tang Y, Jiang Z, Luo Y, Zhao X, Wang L, Norris C, Tian XC. Differential effects of Akt isoforms on somatic cell reprogramming. J Cell Sci. 2014 Sep 15;127(Pt 18):3998-4008. doi: 10.1242/jcs.150029. Epub 2014 Jul 18. PubMed PMID: 25037569.
  • Tang Y, Luo Y, Jiang Z, Ma Y, Lin CJ, Kim C, Carter MG, Amano T, Park J, Kish S, Tian XC. Jak/Stat3 signaling promotes somatic cell reprogramming by epigenetic regulation. Stem Cells. 2012 Dec;30(12):2645-56. doi: 10.1002/stem.1225. PubMed PMID: 22968989.
  • Jiang Z, Zhang M, Lin Y, Zhu J, Li M, Luo Y and Gan X. Complete Mitochondrial Genome Sequence and Phylogenetic Analysis of Oreochromis Aureus. Journal of Fishery Sciences of China. 2011, 18(4):790-800.
  • Zhu J, Chen S, Bi J, Jiang Z, Luo Y, Ma H, Gan X. Genetic Diversity between Sexes of Genetic Improvement of Farmed Tilapia Reveal by SSR Analysis. Genomics and applied biology. 2010, 29(1):1117-1120.

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